Acinetobacter baumannii research group FOR 2251

List of Publications

2017

Nicholas, T., Wolff, H., Djahanschiri, B., Grundmann, F., Kronenwerth, M., Shi, Y., Simonyi, S., Grün, P., Shapiro-Ilan, D., Pidot, S., Stinear, T., Ebersberger, I., and Helge Bode, H. (2017) Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus. Nature Microbiology, in press.

Higgins, P.G., Prior, P., Harmsen, D., Seifert, H. (2017) Development and evaluation of a core genome multilocus typing scheme for whole-genome sequence-based typing of Acinetobacter baumannii. PLoS One. 2017. 12:e0179228

Evans, S.R., Hujer, A.M., Jiang, H., Hill, C.B., Hujer, K.M., Mediavilla, J.R., Manca, C., Tran, T.T., Domitrovic, T.N., Higgins, P.G., Seifert, H., Kreiswirth, B.N., Patel, R., Jacobs, M.R., Chen, L., Sampath, R., Hall, T., Marzan, C., Fowler, V.G. Jr., Chambers, H.F., Bonomo, R.A.; Antibacterial Resistance Leadership Group (ARLG) (2017)  Informing antibiotic treatment decisions: evaluating rapid molecular diagnostics (RMDs) to identify susceptibility and resistance to carbapenems against Acinetobacter spp. PRIMERS III.  J. Clin. Microbiol. 55: 134-144

Lopalco, P., Stahl, J., Annese, C., Averhoff, B., Corcelli, A. (2017) Identification of unique cardiolipin and monolysocardiolipin species in Acinetobacter baumannii. Scientific Reports 7, doi:10.1038/s41598-017-03214-w

Blaschke, U., Wilharm, G. (2017) Complete genome sequence of Acinetobacter sp. strain NCu2D-2 isolated from a mouse. Genome Announc. 5:e01415-16

2016

Nowak, J., Schneiders, T., Seifert, H., Higgins, P.G. (2016) The Asp20?Asn substitution in the response regulator AdeR leads to enhanced efflux activity of AdeB in Acinetobacter baumannii. Antimicrob Agents Chemother 60 : 1085-1090

Zander, E., Seifert, H., Higgins, P.G. (2016) Effects of saline, an ambient acidic environment, and sodium salicylate on OXA-mediated carbapenem resistance in Acinetobacter baumannii. Antimicrob Agents Chemother. 60 : 3415-3418

Komp Lindgren, P., Higgins, P.G., Seifert, H., Cars, O. (2016) Prevalence of hypermutators among clinical Acinetobacter baumannii isolates. J. Antimicrob. Chemother. 71 : 661-665

Lytvynenko, I., Brill, S., Oswald, C., Pos, K. M.* (2016) Molecular basis of polyspecificity of the small multidrug resistance efflux pump AbeS from Acinetobacter baumannii. J. Mol. Biol. 428 : 644-657

Higgins, P.G., Chan, J.Z.-M., Pallen, M.J., Seifert, H., Millard, A.D. (2016) Draft genome sequence of 11 clinical isolates of Acinetobacter baumannii. Genome announcement 4 : e00269-16

Vargiu, A. V., Pos, K. M., Poole, K., Nikaido, H. (2016) Bad Bugs in the XXIst Century: Resistance Mediated by Multi-Drug Efflux Pumps in Gram-Negative Bacteria. Front Microbiol. 7 : 833

Averhoff, B. (2015) Acinetobacter baumannii - understanding and fighting a new emerging pathogen. Environ. Microbiol. 7 : 6-8

Poppel, M.T., Skiebe, E., Laue, M., Bergmann, H., Ebersberger, I., Garn, T., Fruth, A., Baumgardt, S., Busse, H.J., Wilharm, G. (2016) Acinetobacter equi sp. nov. isolated from horse faeces. Int. J. Syst. Evol. Microbiol. 66 : 881-888

Koenigs, A., Stahl, J., Averhoff, B., Göttig, S., Wichelhaus, T.A., Wallich, R., Zipfel, P.F., Kraiczy, P. (2016) CipA of Acinetobacter baumannii is a novel plasminogen and complement binding protein. J. Infect. Dis. 213 : 1388-1399

Scholz, A., Stahl, J., de Berardinis, V., Müller, V., Averhoff, B. (2016) Osmotic stress response in Acinetobacter baylyi: Identification of a glycine-betaine biosynthesis pathway and regulation of osmoadaptive choline uptake and glycine betaine synthesis through a choline-responsive BetI repressor. Environ. Microbiol. Reports 8 : 316-322

2015

Nowak, J., Seifert, H., Higgins, P.G. (2015) Prevalence of eight RND-efflux pump genes in epidemiologically characterised Acinetobacter baumannii of worldwide origin. J. Med. Microbiol. 64 : 630-635

Weidensdorfer, M., Chae, J.I., Makobe, C., Stahl, J., Averhoff, B., Müller, V., Schürmann, C., Brandes, R., Wilharm, G., Ballhorn, W., Christ, S., Linke, D., Fischer, D., Göttig, S., Kempf, V. (2015) Analysis of endothelial adherence of Bartonella henselae and Acinetobacter baumannii using a dynamic human ex vivo infection model. Infect. Immun. 84 : 711-722

Stahl, J., Bergmann, H., Göttig, S., Ebersberger, I., Averhoff, B. (2015) Acinetobacter baumannii virulence is mediated by the concerted action of three phospholipases D. PLoS ONE 10: e0138360

Nemec, A., Krizova, L., Maixnerova, M., Sedo, O., Brisse, S., and Higgins, P. G. (2015) Acinetobacter seifertii sp. nov., a member of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex isolated from human clinical specimens. Int. J. Syst. Evol. Microbiol. 65 : 934-942

Averhoff, B. (2015) Acinetobacter baumannii - understanding and fighting a new emerging pathogen. Environ. Microbiol. 7 : 6-8

Waidmann, O., Kempf, V. A., Brandt, C., Zeuzem, S., Piiper, A., and Kronberger, B. (2015) Colonisation with multidrug-resistant bacteria is associated with increased mortality in patients with cirrhosis. Gut 64 : 1183-1184

Sand, M., Rodrigues, M., Gonzalez, J. M., de Crecy-Lagard, V., Santos, H., Müller, V., and Averhoff, B. (2015) Mannitol-1-phosphate dehydrogenases/phosphatases: a family of novel bifunctional enzymes for bacterial adaptation to osmotic stress. Environ. Microbiol. 17 : 711-719

2014

Goettig, S., Gruber, T. M., Higgins, P. G., Wachsmuth, M., Seifert, H., and Kempf, V. A. (2014) Detection of pan drug-resistant Acinetobacter baumannii in Germany. J. Antimicrob. Chemother. 69 : 2578-2579

Sand, M., Stahl, J., Waclawska, I., Ziegler, C., and Averhoff, B. (2014) Identification of an osmo-dependent and an osmo-independent choline transporter in Acinetobacter baylyi: implications in osmostress protection and metabolic adaptation. Environ. Microbiol. 16 : 1490-1502

Zander, E., Bonnin, R. A., Seifert, H., and Higgins, P. G. (2014) Characterization of blaOXA-143 variants in Acinetobacter baumannii and Acinetobacter pittii. Antimicrob. Agents. Chemother. 58 : 2704-2708

Zander, E., Seifert, H., and Higgins, P. G. (2014) Insertion sequence IS18 mediates overexpression of blaOXA-257 in a carbapenem-resistant Acinetobacter bereziniae isolate. J. Antimicrob. Chemother. 69 : 270-271

Heindorf, M., Kadari, M., Heider, C., Skiebe, E., and Wilharm, G. (2014) Impact of Acinetobacter baumannii superoxide dismutase on motility, virulence, oxidative stress resistance and susceptibility to antibiotics. PLoS One 9, e101033

Kleinkauf, N., Hausemann, A., Kempf, V. A., Gottschalk, R., and Heudorf, U. (2014) Burden of carbapenem-resistant organisms in the Frankfurt/Main Metropolitan Area in Germany 2012/2013 - first results and experiences after the introduction of legally mandated reporting. BMC Infect. Dis. 14 : 446

Zander, E., Fernández-González, A., Schleicher, X., Dammhayn, C., Kamolvit, W., Seifert, H., and Higgins, P. G. (2014) Worldwide dissemination of acquired carbapenem-hydrolysing class D & beta-lactamases in Acinetobacter spp. other than Acinetobacter baumannii. Int. J. Antimicrob. Agents 43 : 375-377

Hischebeth, G.T., Wimmer, M.D., Molitor, E., Seifert, H., Gravius, S., Bekeredjian-Ding, I. (2014) Multidrug resistant Acinetobacter baumannii reaches a new frontier: prosthetic hip joint infection. Infection 43 : 95-97

2013

Wilharm, G., Piesker, J., Laue, M., and Skiebe, E. (2013) DNA uptake by the nosocomial pathogen Acinetobacter baumannii occurs during movement along wet surfaces. J. Bacteriol. 195 : 4146-4153

Higgins, P. G., Perez-Llarena, F. J., Zander, E., Fernandez, A., Bou, G., and Seifert, H. (2013) OXA-235, a novel class D beta-lactamase involved in resistance to carbapenems in Acinetobacter baumannii. Antimicrob. Agents. Chemother. 57 : 2121-2126

Proschak, A., Lubuta, P., Gruen, P., Loehr, F., Wilharm, G., De Berardinis, V., and Bode, H. B. (2013) Structure and biosynthesis of fimsbactins A-F, siderophores from Acinetobacter baumannii and Acinetobacter baylyi. Chembiochem. 14 : 633-638

Schleicher, X., Higgins, P. G., Wisplinghoff, H., Koerber-Irrgang, B., Kresken, M., and Seifert, H. (2013) Molecular epidemiology of Acinetobacter baumannii and Acinetobacter nosocomialis in Germany over a 5-year period (2005-2009). Clin. Microbiol. Infect. 19 : 737-742

Sand, M., Mingote, I., A., Santos, H., Müller, V., and Averhoff, B. (2013) Mannitol, a compatible solute synthesized by Acinetobacter baylyi in a two-step pathway including a salt-induced and salt-dependent mannitol-1-phosphate dehydrogenase. Environ. Microbiol. 15 : 2187–2197

Zander, E., Chmielarczyk, A., Heczko, P., Seifert, H., and Higgins, P. G. (2013) Conversion of OXA-66 into OXA-82 in clinical Acinetobacter baumannii isolates and association with altered carbapenem susceptibility. J. Antimicrob. Chemother. 68 : 308-311

Zander, E., Higgins, P. G., Fernández-González, A., and Seifert, H. (2013) Detection of intrinsic blaOXA-51-like by multiplex PCR on its own is not reliable for the identification of Acinetobacter baumannii. Int. J. Med. Microbiol. 303 : 88-89

Choi, J.Y., Ko, G., Jheong, W., Huys, G., Seifert, H., Dijkshoorn, L., Ko, K.S. (2013) Acinetobacter kookii sp. nov., isolated from soil. Int. J. Syst. Evol. Microbiol. 63 : 4402–4406

Müller, V., Kempf, V.A.J. (2014) Acinetobacter baumannii – ein Pathogen mit zunehmender Bedeutung. Biospektrum 20 : 703